Heightened orofacial, manual, and gait variability in Parkinson's disease results from a general rhythmic impairment.

ABSTRACT: Individuals with Parkinson's disease (PD) experience rhythm disorders in a number of motor tasks, such as (i) oral diadochokinesis, (ii) finger tapping, and (iii) gait. These common motor deficits may be signs of "general dysrhythmia", a central disorder spanning across effectors and tasks, and potentially sharing the same neural substrate. However, to date, little is known about the relationship between rhythm impairments across domains and effectors. To test this hypothesis, we assessed whether rhythmic disturbances in three different domains (i.e., orofacial, manual, and gait) can be related in PD. Moreover, we investigated whether rhythmic motor performance across these domains can be predicted by rhythm perception, a measure of central rhythmic processing not confounded with motor out

SUBMITTER: Puyjarinet F 

PROVIDER: S-EPMC6761142 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature