Ontology highlight
ABSTRACT:
SUBMITTER: Urbani A
PROVIDER: S-EPMC6761146 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190925 1
The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca<sup>2+</sup> dissipates the H<sup>+</sup> gradient generated by ATP hydrolysis. After incorporation of the same preparation into planar lipid bilayers Ca<sup>2+</sup> elicits currents matching those of the MMC/PTP. Currents were fully reversib ...[more]