Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6761178 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190925 1
Despite remarkable success of immune checkpoint inhibitors, the majority of cancer patients have yet to receive durable benefits. Here, in order to investigate the metabolic alterations in response to immune checkpoint blockade, we comprehensively profile serum metabolites in advanced melanoma and renal cell carcinoma patients treated with nivolumab, an antibody against programmed cell death protein 1 (PD1). We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mechan ...[more]