Fluoxetine Exposure During Sexual Development Disrupts the Stress Axis and Results in Sex- and Time- Dependent Effects on the Exploratory Behavior in Adult Zebrafish Danio rerio.

ABSTRACT: The antidepressant fluoxetine (FLX), generally the first line of pharmacological treatment in adolescents and pregnant women with affective disorders, is an emerging endocrine disruptor that is also released to the environment through sewage. Recently, we demonstrated that FLX exposure during the first 6 days of life in zebrafish (ZF; Danio rerio) induced a male-specific reduction in the exploratory behavior in the adult ZF that was linked to a reduction in cortisol production that persisted across three generations. Here we investigated sex differences in the behavioral and stress responses following FLX (0.54 and 54 μg^⋅L^-1) exposure during two periods of sexual development in ZF; early (0-15 days post-fertilization, dpf) and late (15-42 dpf). Our findings rev

SUBMITTER: Vera-Chang MN 

PROVIDER: S-EPMC6761223 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature