Epigenetic Biomarkers in the Management of Ovarian Cancer: Current Prospectives.

ABSTRACT: Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in its early stage remains challenging due to non-specific symptoms in the early-stage of the disease, their presentation at an advanced stage and poor survival. Therefore, improved detection methods are urgently needed. In this article, we summarize the potential clinical utility of epigenetic signatures like DNA methylation, histone modifications, and microRNA dysregulation, which play important role in ovarian carcinogenesis and discuss its application in development of diagnostic, prognostic, and predictive biomarkers. Molecular characterization of epigenetic modification (methylation) in circulating cell fre

SUBMITTER: Singh A 

PROVIDER: S-EPMC6761254 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature