CB₁ and LPA₁ Receptors Relationship in the Mouse Central Nervous System.

ABSTRACT: Neurolipids are a class of bioactive lipids that are produced locally through specific biosynthetic pathways in response to extracellular stimuli. Neurolipids are important endogenous regulators of neural cell proliferation, differentiation, oxidative stress, inflammation and apoptosis. Endocannabinoids (eCBs) and lysophosphatidic acid (LPA) are examples of this type of molecule and are involved in neuroprotection. The present study analyzes a possible relationship of the main receptor subtypes for both neurolipid systems that are present in the central nervous system, the CB₁ and LPA₁ receptors, by using brain slices from CB₁ KO mice and LPA₁-null mice. Receptor-mediated G protein activation and glycerophospholipid regulation of potential precur

SUBMITTER: Gonzalez de San Roman E 

PROVIDER: S-EPMC6761275 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature