Integrative Analysis of miRNA and mRNA Expression Profiles Associated With Human Atrial Aging.

ABSTRACT:

Background

Limited findings have been reported to systematically study miRNA and mRNA expression profiles in aged human atria. In this study, we aimed to identify miRNAs, genes, and miRNA-mRNA interaction networks for human atrial aging (AA).

Methods

Right atrial appendages from twelve patients who received aortic valve replacement were subjected to miRNA-seq and RNA-seq. All the patients were in sinus rhythm (SR) and stratified by age into four groups. Differential expression analysis was carried out to identify miRNAs and genes for human AA. The miRNA-mRNA interactions for human AA were identified by Pearson correlation analysis and miRNA target prediction programs.

Results

Seven miRNAs (4 upregulation and 3 downregulation) and 42 genes (23 upregulation and 19 downr

SUBMITTER: Yao Y 

PROVIDER: S-EPMC6761282 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature