Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength.

ABSTRACT: Pannexins (Panxs), glycoproteins that oligomerize to form hemichannels on the cell membrane, are topologically similar to connexins, but do not form cell-to-cell gap junction channels. There are 3 members of the family, 1-3, with Panx1 being the most abundant. All Panxs are expressed in bone, but their role in bone cell biology is not completely understood. We now report that osteocytic Panx1 deletion (Panx1^Δot) alters bone mass and strength in female mice. Bone mineral density after reaching skeletal maturity is higher in female Panx1^Δot mice than in control Panx1^fl/fl mice. Further, osteocytic Panx1 deletion partially prevented aging effects on cortical bone structure and mechanical properties. Young 4-month-old female Panx1^Δot mice exhibited i

SUBMITTER: Aguilar-Perez A 

PROVIDER: S-EPMC6761284 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature