Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection.

ABSTRACT: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood. Although risk factors for RSV infection have been identified, the role of microbial species in the respiratory tract is only partially known. We aimed to understand the impact of interactions between the nasal microbiome and host transcriptome on the severity and clinical outcomes of RSV infection. We used 16 S rRNA sequencing to characterize the nasal microbiome of infants with RSV infection. We used RNA sequencing to interrogate the transcriptome of CD4⁺ T cells obtained from the same set of infants. After dimension reduction through principal component (PC) analysis, we performed an integrative analysis to identify significant co-variation

SUBMITTER: Sonawane AR 

PROVIDER: S-EPMC6761288 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature