Consideration of Age Is Necessary for Increasing the Accuracy of the AJCC TNM Staging System of Pancreatic Neuroendocrine Tumors.

ABSTRACT: Purpose: Currently, of the two most common staging systems of pancreatic neuroendocrine tumors (pNETs) one is from the European Neuroendocrine Tumor Society (ENETS) and the other is from the American Joint Committee on Cancer (AJCC). However, there are imperfections in both these staging systems. Patients and methods: Patients were selected retrospectively from the Surveillance Epidemiology and End Results (SEER) database (2004 to 2013). The effect of age on the hazard ratio (HR) was evaluated using restricted cubic splines. The discriminatory power of the staging systems was determined using the concordance index (C-index). Results: A total of 3,034 patients with pNETs were included in the final analyses. The risk of death increased slowly along with age for patients

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6761294 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature