Effects of Cell Differentiation on the Phagocytic Activities of IgM⁺ B Cells in a Teleost Fish.

ABSTRACT: Teleost B cells have phagocytic activities for ingesting particulate antigens, such as bacteria, in addition to the functional secretion of immunoglobulins (Igs). In the present study, the phagocytic activities of IgM⁺ B cells under various differentiational conditions residing in peripheral blood leukocytes were investigated in a teleost fish Nile tilapia (Oreochromis niloticus). The IgM⁺ B cells were recognized as IgM^lo or IgM^hi subsets based on their membrane IgM (mIgM) levels. The mIgM, secreted IgM (sIgM), major histocompatibility complex class II and reactive oxygen species were detected. Expressions of transcription factors (Pax5 and Blimp-1) and B cell signaling molecules (CD79a, CD79b, BLNK, and LYN) suggested that IgM^lo

SUBMITTER: Wu L 

PROVIDER: S-EPMC6761302 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature