Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane.

ABSTRACT: Burkholderia comprises species that are significant biothreat agents and common contaminants of pharmaceutical production facilities. Their extreme antibiotic resistance affects all classes of antibiotics, including polycationic polymyxins and aminoglycosides. The major underlying mechanism is the presence of two permeability barriers, the outer membrane with modified lipid A moieties and active drug efflux pumps. The two barriers are thought to be mechanistically independent and act synergistically to reduce the intracellular concentrations of antibiotics. In this study, we analyzed the interplay between active efflux pumps and the permeability barrier of the outer membrane in Burkholderia thailandensis We found that three efflux pumps, AmrAB-OprA, BpeEF-OprC, and BpeAB-OprB, of B. thaila

SUBMITTER: Krishnamoorthy G 

PROVIDER: S-EPMC6761493 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature