Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium.

ABSTRACT: Daptomycin binds to bacterial cell membranes and disrupts essential cell envelope processes, leading to cell death. Bacteria respond to daptomycin by altering their cell envelopes to either decrease antibiotic binding to the membrane or by diverting binding away from septal targets. In Enterococcus faecalis, daptomycin resistance is typically coordinated by the three-component cell envelope stress response system, LiaFSR. Here, studying a clinical strain of multidrug-resistant Enterococcus faecium containing alleles associated with activation of the LiaFSR signaling pathway, we found that specific environments selected for different evolutionary trajectories, leading to high-level daptomycin resistance. Planktonic environments favored pathways that increased cell surface char

SUBMITTER: Prater AG 

PROVIDER: S-EPMC6761497 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature