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Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility.

ABSTRACT: We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the ?-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain. The complex dynamics of KPC (Klebsiella pneumoniae carbapenemase) described here highlight several key diagnostic and therapeutic considerations.

SUBMITTER: Munoz-Price LS 

PROVIDER: S-EPMC6761506 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility.

Munoz-Price L Silvia LS   Reeme Allison E AE   Buchan Blake W BW   Mettus Roberta T RT   Mustapha Mustapha M MM   Van Tyne Daria D   Shields Ryan K RK   Doi Yohei Y  

Antimicrobial agents and chemotherapy 20190923 10

We report patient-to-patient transmission of <i>Enterobacter hormaechei</i> isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain. The complex dynamics of KPC (<i>Klebsiella pne  ...[more]

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