Th2 CD4⁺ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension.

ABSTRACT: Background Inflammation underlies many forms of pulmonary hypertension (PH), including that resulting from Schistosoma infection, a major cause of PH worldwide. Schistosomiasis-associated PH is proximately triggered by embolization of parasite eggs into the lungs, resulting in localized type 2 inflammation. However, the role of CD4⁺ T cells in this disease is not well defined. Methods and Results We used a mouse model of schistosomiasis-associated PH, induced by intraperitoneal egg sensitization followed by intravenous egg challenge, with outcomes including right ventricle systolic pressure measured by cardiac catheterization, and cell density and phenotype assessed by flow cytometry. We identified that embolization of Schistosoma eggs into lungs of egg-sensitized mice increased

SUBMITTER: Kumar R 

PROVIDER: S-EPMC6761627 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature