Helix-Based RNA Landscape Partition and Alternative Secondary Structure Determination.

ABSTRACT: RNA is a versatile macromolecule with the ability to fold into and interconvert between multiple functional conformations. The elucidation of the RNA folding landscape, especially the knowledge of alternative structures, is critical to uncover the physical mechanism of RNA functions. Here, we introduce a helix-based strategy for RNA folding landscape partition and alternative secondary structure determination. The benchmark test of 27 RNAs involving alternative stable structures shows that the model has the ability to divide the whole landscape into distinct partitions at the secondary structure level and predict the representative structures for each partition. Furthermore, the predicted structures and equilibrium populations of metastable conformations for the 2'dG-sensing riboswitch rev

SUBMITTER: Wang F 

PROVIDER: S-EPMC6761681 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature