Pretreatment integrase strand transfer inhibitor resistance in North Carolina from 2010-2016.

ABSTRACT:

Objective

We sought to define the prevalence of pretreatment integrase strand transfer inhibitor (INSTI) resistance and assess the transmission networks of those with pretreatment INSTI resistance.

Design

A retrospective cohort study of HIV-positive patients with genotypic resistance testing sent to a single referral laboratory in North Carolina between 2010 and 2016.

Methods

We linked genotype and public health data for in-care HIV-positive individuals to determine the prevalence of INSTI resistance among treatment-naive (defined as those with a first genotype ≤3 months after diagnosis) and treatment-experienced (defined as those with a first genotype >3 months after diagnosis) patients. We performed molecular and phylogenetic analyses to assess whether pretreatment

SUBMITTER: Menza TW 

PROVIDER: S-EPMC6761699 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature