The kidney transcriptome, from single cells to whole organs and back.

ABSTRACT:

Purpose of review

Transcriptome analysis of human kidney samples provides an integrated output of genetic, physiological, or environmental inputs. This review summarizes recent findings including gene expression and genetic variation integration, bulk and single cell gene expression analysis, and describes how such studies have improved our understanding of kidney disease development.

Recent findings

Bulk or whole tissue analysis of patient kidney samples identified a large number of genes, whose levels correlate with kidney function and/or structural damage. These genes were enriched for metabolic and immune functions. Using expression quantitative trait analysis, genetic variations-driven gene expression can be identified. Recent developments in single cell sequencing defi

SUBMITTER: Huang S 

PROVIDER: S-EPMC6761926 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature