A new computational drug repurposing method using established disease-drug pair knowledge.

ABSTRACT:

Motivation

Drug repurposing is a potential alternative to the classical drug discovery pipeline. Repurposing involves finding novel indications for already approved drugs. In this work, we present a novel machine learning-based method for drug repurposing. This method explores the anti-similarity between drugs and a disease to uncover new uses for the drugs. More specifically, our proposed method takes into account three sources of information: (i) large-scale gene expression profiles corresponding to human cell lines treated with small molecules, (ii) gene expression profile of a human disease and (iii) the known relationship between Food and Drug Administration (FDA)-approved drugs and diseases. Using these data, our proposed method learns a similarity metric through a supervised

SUBMITTER: Saberian N 

PROVIDER: S-EPMC6761937 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature