Phylogenetic Methods Inconsistently Predict the Direction of HIV Transmission Among Heterosexual Pairs in the HPTN 052 Cohort.

ABSTRACT:

Background

We evaluated use of phylogenetic methods to predict the direction of human immunodeficiency virus (HIV) transmission.

Methods

For 33 pairs of HIV-infected patients (hereafter, "index patients") and their partners who acquired genetically linked HIV infection during the study, samples were collected from partners and index patients close to the time when the partner seroconverted (hereafter, "SC samples"); for 31 pairs, samples collected from the index patient at an earlier time point (hereafter, "early index samples") were also available. Phylogenies were inferred using env next-generation sequences (1 tree per pair/subtype). The direction of transmission (DoT) predicted from each tree was classified as correct or incorrect on the basis of which sequences (those f

SUBMITTER: Rose R 

PROVIDER: S-EPMC6761953 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature