FORESEE: a tool for the systematic comparison of translational drug response modeling pipelines.

ABSTRACT:

Summary

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we introduce the uniFied translatiOnal dRug rESponsE prEdiction platform FORESEE, an open-source R-package. FORESEE not only provides a uniform data format for public cell line and patient datasets, but also establishes a standardized environment for drug response prediction pipelines, incorporating various state-of-the-art pre-processing methods, model training algorithms and validation techniques. The modular implementation of individual elements of the pipeline facilitates a straightforward development of combinator

SUBMITTER: Turnhoff LK 

PROVIDER: S-EPMC6761955 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature