Generation of TD₅₀ values for carcinogenicity study data.

ABSTRACT: Carcinogenic potency is a key factor in the understanding of chemical risk assessment. Measures of carcinogenic potency, for example TD₅₀, are instrumental in the determination of metrics such as the threshold of toxicological concern (TTC), acceptable intake (AI) and permitted daily exposure (PDE), which in turn impact on human exposure. The Carcinogenic Potency Data Base (CPDB) has provided a source of study information, complete with calculated TD₅₀ values. However, this is no longer actively updated. An understanding of carcinogenic potency, which can be derived from dose-response data, can be used as part of human risk assessments to generate safety thresholds under which cancer risk is judged to be minimal. The aim of this paper is to produce a transparent metho

SUBMITTER: Thresher A 

PROVIDER: S-EPMC6762014 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature