Systems analysis-based assessment of post-treatment adverse events in lymphatic filariasis.

ABSTRACT:

Background

Lymphatic filariasis (LF) is a neglected tropical disease, and the Global Program to Eliminate LF delivers mass drug administration (MDA) to 500 million people every year. Adverse events (AEs) are common after LF treatment.

Methodology/principal findings

To better understand the pathogenesis of AEs, we studied LF-patients from a treatment trial. Plasma levels of many filarial antigens increased post-treatment in individuals with AEs, and this is consistent with parasite death. Circulating immune complexes were not elevated in these participants, and the classical complement cascade was not activated. Multiple cytokines increased after treatment in persons with AEs. A transcriptomic analysis was performed for nine individuals with moderate systemic AEs and nine mat

SUBMITTER: Andersen BJ 

PROVIDER: S-EPMC6762072 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature