The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus.

ABSTRACT: Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing in this fungus. Our studies revealed that (i) GrxD is essential for growth; (ii) expression of the encoding gene, grxD, is repressed by the transcription factor SreA in iron replete conditions and upregulated during iron starvation; (iii) during iron starvation but not iron sufficiency, GrxD displays predominant nuclear localization; (iv) downregulation of grxD expression results in de-repression of genes involved in iron-dependent pathways and repression of genes involved in iron acquisition during iron starvation, but did not significantly aff

SUBMITTER: Misslinger M 

PROVIDER: S-EPMC6762210 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature