Imputation of canine genotype array data using 365 whole-genome sequences improves power of genome-wide association studies.

ABSTRACT: Genomic resources for the domestic dog have improved with the widespread adoption of a 173k SNP array platform and updated reference genome. SNP arrays of this density are sufficient for detecting genetic associations within breeds but are underpowered for finding associations across multiple breeds or in mixed-breed dogs, where linkage disequilibrium rapidly decays between markers, even though such studies would hold particular promise for mapping complex diseases and traits. Here we introduce an imputation reference panel, consisting of 365 diverse, whole-genome sequenced dogs and wolves, which increases the number of markers that can be queried in genome-wide association studies approximately 130-fold. Using previously genotyped dogs, we show the utility of this reference panel in ident

SUBMITTER: Hayward JJ 

PROVIDER: S-EPMC6762211 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature