An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.

ABSTRACT: Appropriate development of nervous system connectivity involves a variety of processes, including neuronal life-and-death decisions, differentiation, axon guidance and migration, and synaptogenesis. Although these activities likely require specialized signaling events, few substrates unique to these neurotrophic functions have been identified. Here we describe the cloning of ankyrin repeat-rich membrane spanning (ARMS), which encodes a novel downstream target of neurotrophin and ephrin receptor tyrosine kinases, Trk and Eph, respectively. The amino acid sequence of ARMS is highly conserved from nematode to human, suggesting an evolutionarily conserved role for this protein. The ARMS protein consists of 1715 amino acids containing four putative transmembrane domains, multiple ankyrin repeat

SUBMITTER: Kong H 

PROVIDER: S-EPMC6762419 | biostudies-literature | 2001 Jan

REPOSITORIES: biostudies-literature