Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.

ABSTRACT: Persistent, unresolved inflammation in the liver represents a key trigger for hepatic injury and fibrosis in various liver diseases and is controlled by classically activated pro-inflammatory macrophages, while restorative macrophages of the liver are capable of reversing inflammation once the injury trigger ceases. Here we have identified a novel role for neutrophils as key contributors to resolving the inflammatory response in the liver. Using two models of liver inflammatory resolution, we found that mice undergoing neutrophil depletion during the resolution phase exhibited unresolved hepatic inflammation, activation of the fibrogenic machinery and early fibrosis. These findings were associated with an impairment of the phenotypic switch of pro-inflammatory macrophages into a restorativ

SUBMITTER: Calvente CJ 

PROVIDER: S-EPMC6763256 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature