Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?

ABSTRACT:

Scope

The action of brain disorders on peripheral metabolism is poorly understood. The impact of traumatic brain injury (TBI) on peripheral organ function and how TBI effects can be influenced by the metabolic perturbation elicited by fructose ingestion are studied.

Methods and results

It is found that TBI affects glucose metabolism and signaling proteins for insulin and growth hormone in the liver; these effects are exacerbated by fructose ingestion. Fructose, principally metabolized in the liver, potentiates the action of TBI on hepatic lipid droplet accumulation. Studies in isolated cultured hepatocytes identify GH and fructose as factors for the synthesis of lipids. The liver has a major role in the synthesis of lipids used for brain function and repair. TBI results in d

SUBMITTER: Rege SD 

PROVIDER: S-EPMC6763319 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature