An in vitro assay and artificial intelligence approach to determine rate constants of nanomaterial-cell interactions.

ABSTRACT: In vitro assays and simulation technologies are powerful methodologies that can inform scientists of nanomaterial (NM) distribution and fate in humans or pre-clinical species. For small molecules, less animal data is often needed because there are a multitude of in vitro screening tools and simulation-based approaches to quantify uptake and deliver data that makes extrapolation to in vivo studies feasible. Small molecule simulations work because these materials often diffuse quickly and partition after reaching equilibrium shortly after dosing, but this cannot be applied to NMs. NMs interact with cells through energy dependent pathways, often taking hours or days to become fully internalized within the cellular environment. In vitro screening tools must capture these phenomena so that cell

SUBMITTER: Price E 

PROVIDER: S-EPMC6763461 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature