Cystatin C and creatinine-based eGFR levels and their correlation to long-term morbidity and mortality in older adults.

ABSTRACT:

Background

The prevailing diagnostic criteria for CKD are age-independent, but have been challenged in light of the eGFR decline associated with normal aging. The stages of CKD communicate magnitude of risk of ESRD, cardiovascular morbidity, and mortality.

Aims

This study aims to provide more insight into the morbidity and mortality associated with eGFR levels corresponding to the current CKD stages in older adults.

Methods

The 2931 older adults in the Good Aging in Skåne study were randomized from the general population. The exposure variable used was eGFR level (CKD-EPI based on creatinine and cystatin C) with eGFR 60-89 mL/min/1.73 m² as a reference; the outcomes were mortality, acute cardiovascular disease, congestive heart failure, and rapid kidney fun

SUBMITTER: Werner K 

PROVIDER: S-EPMC6763515 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature