The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease.

ABSTRACT: Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is the major cause of cardiovascular disease and is a chronic inflammatory disorder in the arteries. Atherosclerosis is characterized by the accumulation of cholesterol, extracellular matrix, and immune cells in the vascular wall. Recently, the collectin surfactant protein-D (SP-D), an important regulator of the pulmonary immune response, was found to be expressed in the vasculature. Several in vitro studies have examined the role of SP-D in the vascular inflammation leading to atherosclerosis. These studies show that SP-D plays a dual role in the development of atherosclerosis. In general, SP-D shows anti-inflammatory properties, and dampens local inflammation in the vessel, as well as systemic infla

SUBMITTER: Colmorten KB 

PROVIDER: S-EPMC6763600 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature