Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal.

ABSTRACT: Occupational exposure to respirable crystalline silica (cSiO₂) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO₂ triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, dietary supplementation with the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) abrogates these responses. Inflammasome activation, IL-1 cytokine release, and death in alveolar macrophages following cSiO₂ exposure are early and critical events that likely contribute to triggering premature autoimmune pathogenesis by this particle. Here we tested the hypothesis that DHA suppresses cSiO₂-induced NLRP3 inflammasome activation, IL-1 cytokine release, and cell death in the macrophage. The mod

SUBMITTER: Wierenga KA 

PROVIDER: S-EPMC6763728 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature