Factors Associated With Successful Discontinuation of Immune Suppression After Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT:

Importance

Immune suppression discontinuation is routinely attempted after allogeneic hematopoietic cell transplantation (HCT) and under current practices may lead to graft-vs-host disease (GVHD)-associated morbidity and death. However, the likelihood and predictive factors associated with successful immune suppression discontinuation after HCT are poorly understood.

Objectives

To examine factors associated with successful immune suppression discontinuation and risk for immune suppression discontinuation failure under conventional HCT approaches and develop a practical tool to estimate successful immune suppression discontinuation likelihood at the clinical point of care.

Design, setting, and participants

Using long-term follow-up data from 2 national Blood and Marrow

SUBMITTER: Pidala J 

PROVIDER: S-EPMC6763979 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature