Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits.

ABSTRACT:

Importance

Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5% to 10% of the general population, although only a small proportion develop psychotic disorders such as schizophrenia. Studying the genetic causes of psychotic experiences in the general population, and its association with the genetic causes of other disorders, may increase the understanding of their pathologic significance.

Objectives

To determine whether genetic liability to psychotic experiences is shared with schizophrenia and/or other neuropsychiatric disorders and traits and to identify genetic loci associated with psychotic experiences.

Design, setting and participants

Analyses of genetic correlation, polygenic risk scores, and copy number variation were per

SUBMITTER: Legge SE 

PROVIDER: S-EPMC6764002 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature