SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

ABSTRACT: Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are exclusively based on published, expert-curated evidence. Using 2,922 annotations for 1,112 genes, we show that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes. Many SynGO terms are significantly overrepresented among gene variations associated with in

SUBMITTER: Koopmans F 

PROVIDER: S-EPMC6764089 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature