Faecal Microbiota Dynamics and their Relation to Disease Course in Crohn's Disease.

ABSTRACT:

Background

Microbial shifts have been associated with disease activity in Crohn's disease [CD], but findings on specific taxa are inconsistent. This may be due to differences in applied methods and cross-sectional study designs. We prospectively examined the faecal microbiota in adult CD patients with changing or stable disease course over time.

Methods

Faeces were collected at two time-points from 15 healthy control individuals [HCs], 35 CD patients who were in remission and who maintained remission [RRs], and 22 CD patients during remission and also during subsequent exacerbation [RAs]. The microbial composition was assessed by 16S rRNA [V4] gene sequencing.

Results

Compared with HCs, patients with CD had a lower microbial richness [p = 0.0002] and diversity [p = 0.

SUBMITTER: Galazzo G 

PROVIDER: S-EPMC6764104 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature