Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis. However, its expression, regulation and clinical significance have not been systematically evaluated in a large number of clinical samples.

Methods

Here, we performed a comprehensive analysis of RUVBL2 based on multiple datasets from 371 liver cancer patients of The Cancer Genome Atlas (TCGA) and on immunohistochemical staining in 153 subjects. In addition, the aberrant signaling pathways caused by RUVBL2 overexpression were investigated.

Results

We demonstrated that promoter hypomethylation, copy number gain, MYC amplification and CTNNB1 mutation were all respon

SUBMITTER: Yan T 

PROVIDER: S-EPMC6764127 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature