Experimental Pulmonary Hypertension Is Associated With Neuroinflammation in the Spinal Cord.

ABSTRACT:

Rationale

Pulmonary hypertension (PH) is a rare but fatal disease characterized by elevated pulmonary pressures and vascular remodeling, leading to right ventricular failure and death. Recently, neuroinflammation has been suggested to be involved in the sympathetic activation in experimental PH. Whether PH is associated with neuroinflammation in the spinal cord has never been investigated.

Methods/results

PH was well-established in adult male Wistar rats 3-week after pulmonary endothelial toxin Monocrotaline (MCT) injection. Using the thoracic segments of the spinal cord, we found a 5-fold increase for the glial fibrillary acidic protein (GFAP) in PH rats compared to controls (p < 0.05). To further determine the region of the spinal cord where GFAP was expressed, we p

SUBMITTER: Vaillancourt M 

PROVIDER: S-EPMC6764190 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature