Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2⁺ Proinflammatory Subset.

ABSTRACT: Brain injury from stroke is typically considered an event exclusive to the CNS, but injury progression and repair processes are profoundly influenced by peripheral immunity. Stroke stimulates an acute inflammatory response that results in a massive infiltration of peripheral immune cells into the ischemic area. While these cells contribute to the development of brain injury, their recruitment has been considered as a key step for tissue repair. The paradoxical role of inflammatory monocytes in stroke raises the possibility that the manipulation of peripheral immune cells before infiltration into the brain could influence stroke outcome. One such manipulation is remote ischemic limb conditioning (RLC), which triggers an endogenous tolerance mechanism. We observed that mice subjected to post

SUBMITTER: Yang J 

PROVIDER: S-EPMC6764204 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature