Effect of donor, component, and recipient characteristics on hemoglobin increments following red blood cell transfusion.

ABSTRACT: Significant research has focused individually on blood donors, product preparation and storage, and optimal transfusion practice. To better understand the interplay between these factors on measures of red blood cell (RBC) transfusion efficacy, we conducted a linked analysis of blood donor and component data with patients who received single-unit RBC transfusions between 2008 and 2016. Hemoglobin levels before and after RBC transfusions and at 24- and 48-hour intervals after transfusion were analyzed. Generalized estimating equation linear regression models were fit to examine hemoglobin increments after RBC transfusion adjusting for donor and recipient demographic characteristics, collection method, additive solution, gamma irradiation, and storage duration. We linked data on 23 194 trans

SUBMITTER: Roubinian NH 

PROVIDER: S-EPMC6764268 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature