Biocompatible and Na⁺-sensitive thin-film transistor for biological fluid sensing.

ABSTRACT: In this study, we develop a Na⁺-sensitive thin-film transistor (TFT) for a biocompatible ion sensor and investigate its cytotoxicity. A transparent amorphous oxide semiconductor composed of amorphous In-Ga-Zn-oxide (a-InGaZnO) is utilized as a channel of the Na⁺-sensitive TFT, which includes an indium tin oxide (ITO) film as the source and drain electrodes and a Ta₂O₅ thin-film gate, onto which a Na⁺-sensitive membrane is coated. As one of the Na⁺-sensitive membranes, the polyvinyl chloride (PVC) membrane with bis(12-crown-4) as the ionophore used on the TFT sensors shows good sensitivity and selectivity to changes in Na⁺ concentration but has high cytotoxicity owing to the leaching of its plasticizer to the solut

SUBMITTER: Ito K 

PROVIDER: S-EPMC6764347 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature