Human leukocyte antigen-DQB1 polymorphisms and haplotype patterns in Guillain-Barre syndrome.

ABSTRACT:

Objective

The etiology of Guillain-Barré syndrome (GBS) remains enigmatic, although genetic and environmental factors are speculated to be associated with this autoimmune condition. We investigated whether polymorphisms and the haplotype structures of the human leukocyte antigen (HLA)-DQB1 gene relate to the autoimmune response to infection and affect the development of GBS.

Methods

HLA-DQB1 polymorphic alleles (*0201, *030x, *0401, *050x, *060x) were determined for 151 Bangladeshi patients with GBS and 151 ethnically matched healthy controls using sequence-specific polymerase chain reaction. Pairwise linkage disequilibrium (LD) and haplotype patterns were analyzed based on D ́statistics and the genotype package in R statistics, respectively. Association studies were conduct

SUBMITTER: Hayat S 

PROVIDER: S-EPMC6764492 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature