Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse.

ABSTRACT:

Objective

To determine the cutoffs that optimized the agreement between ¹⁸ F-Florbetapir positron emission tomography (PET) and Aβ1-42, Aβ1-40, tTau, pTau and their ratios measured in cerebrospinal fluid (CSF) on the LUMIPULSE G600II instrument, we quantified the levels of these four biomarkers in 94 CSF samples from participants of the Sant Pau Initiative on Neurodegeneration (SPIN cohort) using the Lumipulse G System with available ¹⁸ F-Florbetapir imaging.

Methods

Participants had mild cognitive impairment (n = 35), AD dementia (n = 12), other dementias or neurodegenerative diseases (n = 41), or were cognitively normal controls (n = 6). Levels of Aβ1-42 were standardized to certified reference material. Amyloid scans were assessed visually and throug

SUBMITTER: Alcolea D 

PROVIDER: S-EPMC6764494 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature