Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression.

ABSTRACT:

Objectives

Blood biomarkers for cerebral tissue ischemia are lacking. The goal was to identify a blood transcriptomic signature jointly identified in the ischemic brain.

Methods

A nonhuman primate model with middle cerebral artery (MCA) territory infarction was used to study gene expression by microarray during acute ischemic cerebral stroke in the brain and the blood. Brain samples were collected in the infarcted and contralateral non-infarcted cortex as well as blood samples before and after occlusion. Gene expression was compared between the two brain locations to find differentially expressed genes. The expressions of these genes were then compared in the blood pre- and post-occlusion.

Results

Hierarchical clustering of brain expression data revealed strong indepe

SUBMITTER: Ramsay L 

PROVIDER: S-EPMC6764628 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature