Spectral organization of focal seizures within the thalamotemporal network.

ABSTRACT:

Objective

To investigate dynamic changes in neural activity between the anterior nucleus of the thalamus (ANT) and the seizure onset zone (SOZ) in patients with drug-resistant temporal lobe epilepsy (TLE) based on anatomic location, seizure subtype, and state of vigilance (SOV).

Methods

Eleven patients undergoing stereoelectroencephalography for seizure localization were recruited prospectively for local field potential (LFP) recording directly from the ANT. The SOZ was identified using line length and epileptogenicity index. Changes in power spectral density (PSD) were compared between the two anatomic sites as seizures (N = 53) transitioned from interictal baseline to the posttermination stage.

Results

At baseline, the thalamic LFPs were significantly lower and dist

SUBMITTER: Pizarro D 

PROVIDER: S-EPMC6764631 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature