Integrated systems-genetic analyses reveal a network target for delaying glioma progression.

ABSTRACT:

Objective

To identify a convergent, multitarget proliferation characteristic for astrocytoma transformation that could be targeted for therapy discovery.

Methods

Using an integrated functional genomics approach, we prioritized networks associated with astrocytoma progression using the following criteria: differential co-expression between grade II and grade III IDH1-mutated and 1p/19q euploid astrocytomas, preferential enrichment for genetic risk to cancer, association with patient survival and sample-level genomic features. Drugs targeting the identified multitarget network characteristic for astrocytoma transformation were computationally predicted using drug transcriptional perturbation data and validated using primary human astrocytoma cells.

Results

A single netw

SUBMITTER: Laaniste L 

PROVIDER: S-EPMC6764637 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature