Serum and urinary metabolomics and outcomes in cirrhosis.

ABSTRACT:

Background

Cirrhosis can alter several metabolic pathways. Metabolomics could prognosticate outcomes like hepatic encephalopathy (HE), transplant, hospitalization and death.

Aim

Determine changes in serum and urine metabolomics in cirrhotics who develop outcomes.

Methods

Cirrhotic outpatients underwent data, serum/urine collection and were followed for 90 days. Demographics, cirrhosis details and medications were collected. Metabolomics was performed on urine/serum using GC/MS with subsequent bioinformatics analyses (ChemRICH, MetaMAPP and PLS-DA). Logistic regression adjusting for covariates (demographics, alcohol etiology, prior HE, PPI, SBP prophylaxis, rifaximin/lactulose) were performed and ROC curves comparing MELD to adjusted serum & urine metabolites were crea

SUBMITTER: Bajaj JS 

PROVIDER: S-EPMC6764675 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature