Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program.

ABSTRACT: Environmental or genetic perturbations lead to gene expression changes. While most analyses of these changes emphasize the presence of qualitative differences on just a few genes, we now know that changes are widespread. This large-scale variation has been linked to the exclusive influence of a global transcriptional program determined by the new physiological state of the cell. However, given the sophistication of eukaryotic regulation, we expect to have a complex architecture of specific control affecting this program. Here, we examine this architecture. Using data of Saccharomyces cerevisiae expression in different nutrient conditions, we first propose a five-sector genome partition, which integrates earlier models of resource allocation, as a framework to examine the deviations from th

SUBMITTER: Chagoyen M 

PROVIDER: S-EPMC6764696 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature