Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice.

ABSTRACT: Metformin is currently the most effective treatment for type-2 diabetes. The beneficial actions of metformin have been found even beyond diabetes management and it has been considered as one of the most promising drugs that could potentially slow down aging. Surprisingly, the effect of metformin on brain function and metabolism has been less explored given that brain almost exclusively uses glucose as substrate for energy metabolism. We determined the effect of metformin on locomotor and cognitive function in normoglycemic mice. Metformin enhanced locomotor and balance performance, while induced anxiolytic effect and impaired cognitive function upon chronic treatment. We conducted in vitro assays and metabolomics analysis in mice to evaluate metformin's action on the brain metabolis

SUBMITTER: Li W 

PROVIDER: S-EPMC6764722 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature