The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination.

ABSTRACT: In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber tracts, while in the opposite direction, its movement to the adjacent thalamus was completely impeded by a barrier structure, which was identified as the converged, compact myelin fascicle. The regulating and the barrier effects of myelin were unchanged in AQP4-knockout rats but were impaired as the integrity of boundary structure of drainage system was destroyed in a demyelinated rat model. We thus proposed that the brain homeostasis was maintained within each ISF drainage division locally, rather tha

SUBMITTER: Wang A 

PROVIDER: S-EPMC6764732 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature